Long-term antihypertensive effect of renal denervation in resistant hypertension: three years follow-up

Abstract Background Recent studies have shown proven efficacy of renal denervation in arterial hypertension, but there is a continuing need to assess the duration antihypertensive effect. Purpose Evaluation long-term effect patients with resistant hypertension. Methods 125 apparently without comorbidities after 3-week standardized treatment Losartan 100 mg, Amlodipin 10 mg and Indapamid 1.5 confirmation their resistance were randomly assigned into three groups depending on supplemented previously administered: group I - selective I1-imidazoline agonist Moxonidine, II cardioselective beta-blocker Bisoprolol III – artery denervation. The compliance was confirmed using 8-item Morisky Medication Adherence Scale. Renal performed main arteries branches. Patients assessed by ambulatory blood pressure monitoring at baseline, 3, 12, 24 36 months follow-up. Results mean hour systolic (SBP) baseline 179.0±2.02 mmHg versus 177.96±2.44 176.92±1.97 III, p>0.05. A statistically significant reduction SBP m/24 h noted all starting 3 months, undergoing showing superiority over both pharmacological treatment: −6.48±0.81 −6.2±0.88 −23.28±1.9 p<0.001. progressive improvement continued until end study, so years evaluation observational Moxonidine 146.36±1.36 total −32.64±1.56 from −152.88±1.56 −25.08±1.65 133.16±0.73 −282±1.30 diastolic (DBP) increased (105.52±1.28 108.6±1.6 107.24±0.92 p>0.05) similar an authentic maximum DBP registered evaluation, comparative analyses dynamics between presence statistical difference due amelioration this parameter: −18.36±1.88 −16.84±1.76 −28.2±1.30 Conclusions All regimens been be effective reducing superior comparable absolute treatment, beneficial being maintained for period years. Funding Acknowledgement Type funding sources: Public Institution(s). Main source(s): National Agency Research Development